protein

Complement C7 protein

MBS537072

0.25 mg

485 USD

Native Protein

Complement C7 protein

Complement C7

C& protein

complement component C7; Complement component C7; complement component C7; complement component 7

C7; C7

CO7_HUMAN

Human

843

> 98% pure

Supplied as a liquid in PBS, pH 7.2, no preservatives added.

Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.

Source Note: Human serum/plasma. Protein Type: Native. Biological Significance: Native human C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da. C7 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to recently-formed C5b,C6 complexes at the cell membrane. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface.

Biohazard Information: Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Immunology; Native Protein; Complements

Purified Complement C7 protein isolated from human plasma

45580688

NP_000578.2

NM_000587.2

P10643

92.4 kDa

Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Innate Immune System Pathway (106387); Prion Diseases Pathway (101144); Prion Diseases Pathway (100065); Regulation Of Complement Cascade Pathway (576254)

C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: membrane attack complex; extracellular region. Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation. Disease: Complement Component 7 Deficiency

0.25 mg

485 USD