protein

AFP protein

MBS537041

1 mg

350 USD

Native Protein

AFP protein

AFP

alpha-Fetoprotein protein; alpha-Fetoprotein antigen

Alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP

AFP; AFP; AFPD; FETA; HPAFP; HPAFP

FETA_HUMAN

Human

609

> 60% pure

Supplied in 0.1M Phosphate buffer, pH 7.4 with 0.1% NaN3.

4.1mg/ml measured by OD 280nm

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA)

Suitable for use as a calibrator in immunoassays or as an immunogen. Optimal conditions to be determined by end user.

Source Note: Human cord serum. Protein Type: Native. Biological Significance: Alpha-fetoprotein is a protein that in humans is encoded by the AFP gene. This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. Contaminants: Not determined

Biohazard Information: Tested negative for HBsAg, anti-HCV and anti-HIV 1/2 by EIA. This product contains sodium azide as preservative. ALthough the amount of sodium azide is very small appropriate care must be taken when handling this product.

Cancer; Native Protein

Purified native Human AFP protein

Simultaneous multianalysis for tumor markers by antibody fragments microarray system; Shi-Ping Songa, Bin Lia, Jun Hua, Min-Qian Li (Analytica Chimica Acta: Volume: 510 Issue: 2 Page: 147-152 DOI: 10.1016/j.aca.2004.01.020). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein; Young Ju Lee, Seong-Wook Lee (Biochemical and Biophysical Research Communications: Volume: 417 Issue: 1 Page: 521-527 DOI: 10.1016/j.bbrc.2011.11.153)

20379787

AAH27881.1

P02771

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

1 mg

350 USD