protein

Cathepsin G protein

MBS537015

0.1 mg

445 USD

Native Protein

Cathepsin G protein

Cathepsin G

cathepsin G; Cathepsin G; cathepsin G; cathepsin G

CTSG; CTSG; CG; CATG; CG

CATG_HUMAN

Human Neutrophil

255

>98% pure by SDS-PAGE

Lyophilized-salt free. Reconstitute with 50mM Na Acetate, pH 5.5 with 150mM NaCl.

4 degree C shipping only. Upon receipt store at -20 degree C.

User optimized

Protein Type: Native. Biological Significance: Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. This enzyme degrades collagen and proteoglycan and can also cause the release of angiotensin II from angiotensin I or angiotensinogen. It has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Bioactivity: 2-4 units/mg - One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-ala-ala-pro-phe-pNA (1mM) per minute at 25o C in 160 mM Tris-HCl, pH 7.4, with 1.6 M NaCl. Contaminants: None detected by SDS-PAGE. Grade: Immunogen

Biohazard Information: Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. Additional Remarks: Biological activity = 2-4 Units/mg. 1 unit of activity is defined as the amount of enzyme that hydrolyzes 1 uM per minute.

Proteases, Inhibitors, Native Protein

Purified native Human Cathepsin G protein

179915

AAA51919.1

P08311

ACE Inhibitor Pathway (198763); Activation Of Matrix Metalloproteinases Pathway (576264); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Lysosome Pathway (99052); Lysosome Pathway (96865); Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230)

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family. Protein type: Motility/polarity/chemotaxis; Protease; EC 3.4.21.20. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; extracellular space; cell surface; plasma membrane; extracellular region; nucleus; secretory granule. Molecular Function: heparin binding; peptidase activity; serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; positive regulation of immune response; extracellular matrix organization and biogenesis; cellular protein metabolic process; protein processing; response to lipopolysaccharide; immune response; proteolysis; angiotensin maturation; defense response to fungus

0.1 mg

445 USD