protein

Placental Lactogen protein (Preservative-free) (> 95% pure)

MBS537012

1 mg

365 USD

Native Protein

Placental Lactogen protein (Preservative-free) (> 95% pure)

Placental Lactogen

Human Placental Lactogen protein; hPL protein

placental lactogen; Chorionic somatomammotropin hormone 1; chorionic somatomammotropin hormone 1; chorionic somatomammotropin hormone 1 (placental lactogen); Lactogen; Placental lactogen; PL

CSH1; CSH1; PL; CSA; CS-1; CSMT; hCS-1; hCS-A; Choriomammotropin; PL

CSH1_HUMAN

Human

217

> 95% pure

Lyophilized from 100mM NH4(C(=O)OHO).

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Source Note: Human placenta. Protein Type: Native. Biological Significance: Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. Its structure and function is similar to that of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. HPL has anti-insulin properties.

Hormones & Steroids; Native Protein

Purified native Human Placental Lactogen protein (Preservative-free) (> 95% pure)

190034

AAA98621.1

P01243

22 kDa

Cytokine Signaling In Immune System Pathway (366171); Growth Hormone Receptor Signaling Pathway (477128); Immune System Pathway (106386); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nuclear Signaling By ERBB4 Pathway (530744); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979)

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: extracellular region. Molecular Function: metal ion binding; hormone activity

1 mg

365 USD