Transferrin protein (Mouse) | MyBioSource MBS537006 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Transferrin protein (Mouse)

catalog :

MBS537006

quantity :

5 mg

price :

385 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS537006

products type :

Native Protein

products full name :

Transferrin protein (Mouse)

products short name :

[Transferrin]

products name syn :

[TF protein; beta 1 metal binding globulin protein; PRO1557 protein; Apotransferrin protein; DKFZp781D0156 protein; Serotransferrin precursor protein; Siderophilin protein; PRO2086 protein; PRO1400 protein]

other names :

[transferrin; Serotransferrin; serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin]

other gene names :

[TF; TF; TFQTL1; PRO1557; PRO2086; Transferrin]

uniprot entry name :

TRFE_HUMAN

host :

Normal mouse serum

sequence length :

698

purity :

Mouse Transferrin protein was purified by delipidation and selective precipitation followed by dialysis.

form :

Supplied as a liquid in 0.01M Sodium Phosphate, 0.25M NacL, pH 7.2 with no preservatives

concentration :

5.9 mg/ml

storage stability :

Ships ambient or refrigerated. Upon receipt store at 4°C. For extended storage aliquot and freeze at -20°C. Dilute only prior to imediate use.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Mouse Transferrin and anti-Mouse Serum.

other info1 :

Species: Mouse. Protein Type: Native. Contaminants: IEP shows a single precipitin arc against anti-Mouse serum and anti-Mouse Transferrin. Biological Significance: Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. In humans, it is encoded by the TF gene. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kDa and contains 2 specific high-affinity Fe(III) binding sites.

other info2 :

Biohazard: Use normal laboratory precautions when handling reagent

products categories :

Nutrition & Metabolism; Native Protein

products description :

Purified Native Mouse Transferrin protein

ncbi gi num :

248648

ncbi acc num :

AAB22049.1

uniprot acc num :

P02787

ncbi pathways :

EPHB Forward Signaling Pathway (138047); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (187191); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

uniprot summary :

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 3q22.1. Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; late endosome; apical plasma membrane; basal plasma membrane; endosome membrane; vesicle. Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding. Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport. Disease: Atransferrinemia

size1 :

5 mg

price1 :

385 USD

more info or order :

MyBioSource product webpage