protein

Vimentin protein

MBS536607

0.1 mg

645 USD

Native Protein

Vimentin protein

[Vimentin]

[Vimentin protein]

[vimentin; Vimentin; vimentin; vimentin]

[VIM; VIM; HEL113; CTRCT30]

VIME_HUMAN

Bovine

466

> 98% by SDS gel electrophoresis

Lyophilized powder. Reconstitute with 80ul distilled water for a final solution in 10mM sodium phosphate pH 7.5, 6M urea, 2mM DTT, 1mM methylammonium chloride and protein concentration of 1mg/ml.

100ug, lyophilized

Ships ambient or refrigerated. Upon receipt store at 4 degree C. After reconstituted store at -20 degree C.

User optimized

Source Note: Bovine lens. Protein Type: Native. Biological Significance: Vimentin is one of the five major groups of intermediate filaments, a distinct class of cytosekeltal proteins, occurring in mesenchymal cells. Localized vimentin can be detected in fibroblasts, endothelial cells, lymphoid tissues, and melanocytes.

Additional Remarks: Isoelectric Point: pl 5.3

Cell Biology; Native Protein

Purified native Bovine Vimentin Protein

62414289

NP_003371.2

NM_003380.3

P08670

57 kDa

Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Aurora B Signaling Pathway (138080); Caspase Cascade In Apoptosis Pathway (137974); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (105679); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); MicroRNAs In Cancer Pathway (852705)

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Vimentin: an intermediate filament protein. Intermediate filament proteins are expressed in a tissue-specific manner. Desmin is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 10p13. Cellular Component: intermediate filament cytoskeleton; neuron projection; focal adhesion; cytoskeleton; leading edge; cytoplasm; plasma membrane; intermediate filament; peroxisome; cytosol. Molecular Function: protein C-terminus binding; identical protein binding; protein binding; structural constituent of cytoskeleton; double-stranded RNA binding; glycoprotein binding; structural constituent of eye lens. Biological Process: Bergmann glial cell differentiation; viral reproduction; apoptosis; intermediate filament organization; cell motility; astrocyte development; muscle filament sliding; cell structure disassembly during apoptosis. Disease: Cataract 30

0.1 mg

645 USD