MBP protein (Bovine) | MyBioSource MBS536591 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

MBP protein (Bovine)

catalog :

MBS536591

quantity :

10 mg

price :

430 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS536591

products type :

Native Protein

products full name :

MBP protein (Bovine)

products short name :

MBP

products name syn :

MBP protein (Bovine); Bovine Myelin Basic Protein

other names :

MBP, partial; Myelin basic protein; Golli-MBP; myelin basic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein

products gene name :

MBP

other gene names :

MBP; MBP; MBP

uniprot entry name :

MBP_HUMAN

host :

Bovine

sequence length :

160

purity :

MBP protein (Bovine) was purified by SP-sepharose HPLC.

form :

10mM MOPS, pH 7.0, with 0.05% NaN3.

storage stability :

Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles

tested application :

User optimized

other info1 :

Source Note: Bovine Brain. Protein Type: Native. Biological Significance: Myelin basic protein (MBP) is the major extrinsic membrane protein of the central nervous. MBP is important in the process of myelination of nerves in the CNS. Interest in MBP has centered on its role in demyelinating diseases, particularly multiple sclerosis (MS). Several studies have shown a role for antibodies against MBP in the pathogenesis of MS.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

products categories :

Neuroscience; Native Protein

products description :

Purified Bovine MBP protein

ncbi gi num :

49456793

ncbi acc num :

CAG46717.1

uniprot acc num :

P02686

ncbi mol weight :

17,343 Da

ncbi pathways :

Glial Cell Differentiation Pathway (698758); MAPK Cascade Pathway (198834); Neural Crest Differentiation Pathway (672460); Spinal Cord Injury Pathway (739007)

ncbi summary :

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

uniprot summary :

MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 18q23. Cellular Component: compact myelin; internode region of axon; cell soma; plasma membrane; nucleus. Molecular Function: protein binding; structural constituent of myelin sheath; protease binding. Biological Process: myelination; response to mercury ion; synaptic transmission; central nervous system development; substantia nigra development; response to toxin; immune response; negative regulation of axonogenesis; axon ensheathment; response to progesterone stimulus; aging

size1 :

10 mg

price1 :

430 USD

more info or order :

MyBioSource product webpage