NR2F2 antibody | MyBioSource MBS536467 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NR2F2 antibody

catalog :

MBS536467

quantity :

0.1 mg

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow, zebrafish

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS536467

products type :

Antibody

products full name :

NR2F2 antibody

products short name :

NR2F2

products name syn :

Polyclonal NR2F2; Anti-NR2F2; NR2F2; ARP1; SVP40; nuclear receptor subfamily 2; COUP-TFII; NRF-2; MGC117452; member 2; TFCOUP2; group F; COUPTFB; NRF 2

other names :

COUP transcription factor 2 isoform a; COUP transcription factor 2; COUP transcription factor 2; nuclear receptor subfamily 2, group F, member 2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2

products gene name :

NR2F2

other gene names :

NR2F2; NR2F2; ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII; ARP1; TFCOUP2; COUP-TF2; ARP-1; COUP-TF II

uniprot entry name :

COT2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Cow, dog, guinea pig, human, mouse, rat, zebrafish.

sequence length :

414

form :

100ug lyophilzed powder in PBS buffer with 2% sucrose. Reconstitute with 100ul distilled water for a final concentration of 1mg/ml.

concentration :

100ug/lyophilized

storage stability :

Ships ambient or refrigerated. Upon receiving, store at 4 degree C for short term. Store at -20 degree C for long term.

tested application :

Immunohistochemistry (IHC), Western Blot (WB)

app notes :

Optimal conditions to be determined by the end user

other info1 :

Biological Significance: NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.

other info2 :

Immunogen: synthetic peptide directed toward the N terminal of human NR2F2.

products categories :

Signal Transduction

products description :

Rabbit polyclonal NR2F2 antibody

ncbi gi num :

14149746

ncbi acc num :

NP_066285

ncbi gb acc num :

NM_021005.3

uniprot acc num :

P24468

ncbi mol weight :

29,163 Da

ncbi pathways :

Developmental Biology Pathway (477129); FOXA1 Transcription Factor Network Pathway (137979); Nuclear Receptors Pathway (198848); Regulation Of Telomerase Pathway (137987); Transcriptional Regulation Of White Adipocyte Differentiation Pathway (205243)

ncbi summary :

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

uniprot summary :

NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor; DNA-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 15q26. Cellular Component: nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription factor activity. Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cyclin-dependent protein kinase activity; neuron migration; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; fertilization; forebrain development; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; steroid hormone mediated signaling; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation; maternal placenta development. Disease: Congenital Heart Defects, Multiple Types, 4

size1 :

0.1 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage