catalog number :
MBS536214
products full name :
GABABR1 antibody
products short name :
GABABR1
products name syn :
Polyclonal GABABR1; Anti-GABABR1; GABA Receptor Associated Protein Subunit 1
other names :
gamma-aminobutyric acid type B receptor subunit 1 isoform c; Gamma-aminobutyric acid (GABA) B receptor 1 isoform b variant; gamma-aminobutyric acid type B receptor subunit 1; gamma-aminobutyric acid (GABA) B receptor, 1; Gamma-aminobutyric acid (GABA) B receptor 1 isoform b variant
products gene name :
GABABR1
other gene names :
GABBR1; GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2
uniprot entry name :
Q53EM0_HUMAN
reactivity :
To be determined by end-user
purity :
GABABR1 antibody was purified by affinity chromatography.
form :
Affinity purified IgG supplied in PBS with 0.02% NaN3.
concentration :
1.0 mg/ml
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:1,000
other info1 :
Biological Significance: The inhibitory neurotransmitter, GABA, acts through two ligand-gated channels, GABAA and GABAC receptors and GABAB, the latter of which acts through a G protein mechanism. GABABR1 is one of the two G-protein coupled receptors for GABAB that acts as a heteromeric assembly with GABABR2.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: GABABR1 antibody was raised in rabbit using residues 33-54 [PHLPRPHPRVPPHPSSERRAVY] of the GABABR1 subunit as the immunogen.
products categories :
Neuroscience; Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal GABABR1 antibody
ncbi acc num :
NP_068704.2
ncbi gb acc num :
NM_021904.2
ncbi mol weight :
95,134 Da
ncbi pathways :
Activation Of G Protein Gated Potassium Channels Pathway (366226); Activation Of GABAB Receptors Pathway (187181); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); G Alpha (i) Signalling Events Pathway (119550); G Protein Gated Potassium Channels Pathway (366225); GABA B Receptor Activation Pathway (187180); GABA Receptor Activation Pathway (187178); GABAergic Synapse Pathway (377263)
ncbi summary :
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]