MBP antibody | MyBioSource MBS535991 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MBP antibody

catalog :

MBS535991

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535991

products type :

Antibody

products full name :

MBP antibody

products short name :

MBP

products name syn :

Polyclonal MBP; Anti-MBP; Myelin Basic Protein

other names :

Golli-MBP isoform 1; Myelin basic protein; Golli-MBP; myelin basic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein

products gene name :

MBP

other gene names :

MBP; MBP; MBP

uniprot entry name :

MBP_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Reacts with residues 102-116 (DDTNHERERLEQLFE)of the 33 kDa Human, Mouse and Rat MBP.

sequence length :

304

specificity :

Human

purity :

MBP antibody was purified by affinity chromatography.

form :

Affinity purified IgG, supplied as a liquid in PBS containing 0.02% Sodium Azide

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

FC: 1:200-1:500. IHC: 1:100-1:200. WB: 1:500-1:1,000

other info1 :

Biological Significance: Myelin Basic Protein (MBP) functions in the nervous system in myelination and is expressed in oligodendrocytes following differentiation. There are numerous isoforms generated by differential splicing events and post-translational modifications that have specialized functions. These functions include participation in signaling pathways prior to myelination, myelination or the re-myelination process following neural injury.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: MBP antibody was raised in rabbit using residues 49-62 [DRGAPKRGSGKDSH] of the 33 kDa human MBP protein as the immunogen.

products categories :

Neuroscience; Purified Polyclonal Antibodies

products description :

Affinity purified Rabbit polyclonal MBP antibody

ncbi gi num :

68509940

ncbi acc num :

NP_001020272

ncbi gb acc num :

NM_001025101.1

uniprot acc num :

P02686

ncbi mol weight :

17,343 Da

ncbi pathways :

Glial Cell Differentiation Pathway (698758); MAPK Cascade Pathway (198834); Neural Crest Differentiation Pathway (672460); Spinal Cord Injury Pathway (739007)

ncbi summary :

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

uniprot summary :

MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 18q23. Cellular Component: internode region of axon; compact myelin; cell soma; plasma membrane; nucleus. Molecular Function: protein binding; structural constituent of myelin sheath; protease binding. Biological Process: myelination; response to mercury ion; synaptic transmission; substantia nigra development; central nervous system development; response to toxin; negative regulation of axonogenesis; immune response; axon ensheathment; response to progesterone stimulus; aging

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage