product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
Flt3 Ligand antibody
catalog :
MBS535856
quantity :
0.05 mg
price :
310 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS535856
products type :
Antibody
products full name :
Flt3 Ligand antibody
products short name :
Flt3
products name syn :
Polyclonal Flt3 Ligand; Anti-Flt3 Ligand; Flt-3 Ligand; Flt3; Flt-3; Fms-related tyrosine kinase 3 ligand; Flt 3
other names :
Flt3 ligand; Fms-related tyrosine kinase 3 ligand; fms-related tyrosine kinase 3 ligand; fms-related tyrosine kinase 3 ligand; SL cytokine
products gene name :
Flt3
other gene names :
FLT3LG; FLT3LG; FL; FLT3L; Flt3 ligand; Flt3L
uniprot entry name :
FLT3L_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human Flt3 ligand
sequence length :
235
form :
Lyophilized from PBS, pH 7.2.
concentration :
50ug, lyophilized
storage stability :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Inhibition, Western Blot (WB)
app notes :
ELISA: 0.5-2 ug/ml. Inhibition: 4-6 ug/ml. WB: 0.1-0.2 ug/ml
other info1 :
Biological Significance: Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified.
other info2 :
Immunogen: Flt3 Ligand antibody was raised in rabbit using highly pure recombinant human Flt-3 ligand as the immunogen.
products categories :
Cytokines & Growth Factors; Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal Flt3 Ligand antibody
ncbi gi num :
1072037
ncbi acc num :
AAA90949.1
uniprot acc num :
P49771
ncbi mol weight :
17.6 kDa (predicted detection band MW)
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83105)
ncbi summary :
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
uniprot summary :
FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral; Cytokine. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: extracellular space; membrane; integral to membrane. Molecular Function: protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding. Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation
size1 :
0.05 mg
price1 :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!