catalog number :
MBS535855
products full name :
I309 antibody
products short name :
I309
products name syn :
Polyclonal I309; Anti-I309; TCA-3; I-309; I 309; I309; CCL1
other names :
interleukin-2; Interleukin-2; interleukin-2; interleukin 2; T-cell growth factor; TCGF; INN: Aldesleukin
products gene name :
I309
other gene names :
IL2; IL2; IL-2; TCGF; lymphokine; IL-2; TCGF
uniprot entry name :
IL2_HUMAN
reactivity :
To be determined by end-user
form :
Lyophilized from PBS, pH 7.2.
storage stability :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Inhibition, Western Blot (WB)
other info1 :
Biological Significance: Human I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to other CC chemokines.
other info2 :
Immunogen: I309 antibody was raised in rabbit using highly pure recombinant human I-309 as the immunogen.
products categories :
Cytokines & Growth Factors; Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal I309 antibody
ncbi acc num :
CAA01199.1
ncbi mol weight :
8.5 kDa (predicted detection band MW)
ncbi pathways :
AhR Pathway 755436!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Calcium Signaling In The CD4+ TCR Pathway 137941!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957
ncbi summary :
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]