catalog number :
MBS535798
products full name :
Midkine antibody
products short name :
Midkine
products name syn :
Polyclonal Midkine; Anti-Midkine; MK; NEGF-2
other names :
midkine isoform a; Midkine; midkine; midkine (neurite growth-promoting factor 2); Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein
other gene names :
MDK; MDK; MK; ARAP; NEGF2; MK1; NEGF2; MK; ARAP
uniprot entry name :
MK_HUMAN
reactivity :
To be determined by end-user
specificity :
Human midkine
form :
Lyophilized from PBS, pH 7.2.
storage stability :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Inhibition, Western Blot (WB)
other info1 :
Biological Significance: Midkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis.
other info2 :
Immunogen: Midkine antibody was raised in rabbit using highly pure recombinant human Midkine as the immunogen.
products categories :
Neuroscience; Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal Midkine antibody
ncbi acc num :
NP_001012333.1
ncbi gb acc num :
NM_001012333.1
ncbi mol weight :
13.4 kDa (predicted detection band MW)
ncbi pathways :
Glypican 2 Network Pathway 138035!!NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway 771602!!Signal Transduction Pathway 477114!!Signaling By NOTCH Pathway 106485!!Signaling By NOTCH2 Pathway 576272!!Syndecan-4-mediated Signaling Events Pathway 138064
ncbi summary :
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]