OPG antibody | MyBioSource MBS535773 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

OPG antibody

catalog :

MBS535773

quantity :

0.05 mg

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535773

products type :

Antibody

products full name :

OPG antibody

products short name :

OPG

products name syn :

Polyclonal OPG; Anti-OPG

other names :

osteoprotegerin; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b; Osteoclastogenesis inhibitory factor; Osteoprotegerin

products gene name :

OPG

other gene names :

TNFRSF11B; TNFRSF11B; OPG; TR1; OCIF; PDB5; OCIF; OPG

uniprot entry name :

TR11B_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

human OPG

sequence length :

401

form :

Lyophilized from PBS, pH 7.2.

concentration :

50ug lyophilized

storage stability :

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

other info1 :

Biological Significance: Osteoprotegerin is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, OPG inhibits nuclear kappa B (NF-?B) which is a central and rapid acting transcription factor for immune related genes, and a key regulator of inflammation, innate immunity, cell survival and differentiation.

other info2 :

Immunogen: OPG antibody was raised in rabbit using highly pure recombinant human OPG (human Osteoprotegerin) as the immunogen.

products categories :

Cytokines & Growth Factors; Purified Polyclonal Antibodies

products description :

Affinity purified Rabbit polyclonal OPG antibody

ncbi gi num :

2072185

ncbi acc num :

AAB53709.1

uniprot acc num :

O00300

ncbi mol weight :

60-65 kDa (predicted detection band MW)

ncbi pathways :

Apoptosis Modulation And Signaling Pathway (198822); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Monoamine Transport Pathway (198851); Osteoblast Signaling Pathway (198842); Osteoclast Signaling Pathway (198769); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); RANKL/RANK Signaling Pathway (672447)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

TNFRSF11B: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: cytokine activity; receptor activity. Biological Process: response to drug; response to magnesium ion; extracellular matrix organization and biogenesis; response to estrogen stimulus; negative regulation of odontogenesis of dentine-containing teeth; apoptosis; response to arsenic; negative regulation of bone resorption; signal transduction; skeletal development; response to nutrient. Disease: Paget Disease, Juvenile

size1 :

0.05 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage