IL1RA antibody | MyBioSource MBS535760 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL1RA antibody

catalog :

MBS535760

quantity :

0.05 mg

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535760

products type :

Antibody

products full name :

IL1RA antibody

products short name :

IL1RA

products name syn :

Polyclonal IL1RA; Anti-IL1RA; ICIL-1RA; ILRA 1; IL-1Ra; IL-1R alpha; IL1RA; Interleukin 1R alpha; ILRA-1; IL-1RN; IRAP

other names :

interleukin-1 receptor antagonist protein isoform 4; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor; INN: Anakinra

products gene name :

IL1RA

other gene names :

IL1RN; IL1RN; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP

uniprot entry name :

IL1RA_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Not determined

sequence length :

143

form :

Sterile filtered lyophilized powder from PBS, pH 7.2. Centrifuge the vial prior to opening. Reconstitute in sterile water to a final concentration of 0.1-1.0mg/ml.

concentration :

50ug, lyophilized

storage stability :

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

app notes :

ELISA: 0.5-2 ug/ml. Inhibition: 2.5-3.7 ug/ml. WB: 0.1-0.2 ug/ml

other info1 :

Biological Significance: Interleukin-1 receptor antagonist (IL1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.

other info2 :

Immunogen: E.coli derived recombinant Human IL-1RA

products categories :

Cytokines & Growth Factors; Purified Polyclonal Antibodies

products description :

Affinity purified Rabbit polyclonal IL1RA antibody

ncbi gi num :

27894321

ncbi acc num :

NP_776215.1

ncbi gb acc num :

NM_173843.2

uniprot acc num :

P18510

ncbi mol weight :

17.2 kDa (predicted detection band MW)

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Leptin Signaling Pathway (672456); SIDS Susceptibility Pathways (198901); Signaling By Interleukins Pathway (160140)

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle; Secreted, signal peptide; Secreted; Cytokine. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular. Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity. Biological Process: response to drug; positive regulation of JNK activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of glutamate secretion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; fever; sensory perception of pain; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; immune response; lipid metabolic process; response to activity; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis. Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis

size1 :

0.05 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage