ABCB1 antibody | MyBioSource MBS535658 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ABCB1 antibody

catalog :

MBS535658

quantity :

0.05 mg

price :

540 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535658

products type :

Antibody

products full name :

ABCB1 antibody

products short name :

ABCB1

products name syn :

Polyclonal ABCB1; Anti-ABCB1; MDR1; DOXORUBICIN RESISTANCE; Multidrug Resistance 1; Abcb1; multidrug; GP170; ABCB 1; ABCB -1; CD243 antigen; ABCB1; ATP-binding cassette sub-family B (MDR/TAP) member 1; Abcb1b; ABC20

other names :

multidrug resistance protein 1; Multidrug resistance protein 1; multidrug resistance protein 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243

products gene name :

ABCB1

other gene names :

ABCB1; ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MDR1; PGY1

uniprot entry name :

MDR1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

1280

purity :

ABCB1 antibody was purified by affinity chromatography.

form :

Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

IHC-P: 20 ug/ml

other info1 :

Biological Significance: P-glycoprotein is also called ABCB1, ATP-binding cassette sub-family B member 1, MDR1, and PGY1. is a well-characterized ABC-transporter of the MDR/TAP subfamily. P-glycoprotein has also recently been designated CD243 (cluster of differentiation 243). In humans, P-glycoprotein is encoded by the ABCB1 gene and is a member of the superfamily of ATP-binding cassette (ABC) transporters.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: ABCB1 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

products categories :

Cell Biology

products description :

Rabbit polyclonal ABCB1 antibody

ncbi gi num :

42741659

ncbi acc num :

NP_000918

ncbi gb acc num :

NM_000927.4

uniprot acc num :

P08183

ncbi mol weight :

134,032 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Abacavir Transmembrane Transport Pathway (645350); Abacavir Transport And Metabolism Pathway (645349); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Codeine And Morphine Metabolism Pathway (198831); Drug Induction Of Bile Acid Pathway (698755); HIF-1-alpha Transcription Factor Network Pathway (138045)

ncbi summary :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Protein type: Hydrolase; Cell adhesion; Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; EC 3.6.3.44; Transporter. Chromosomal Location of Human Ortholog: 7q21.12. Cellular Component: cell surface; membrane; plasma membrane; integral to membrane. Molecular Function: protein binding; transporter activity; ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding. Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport. Disease: Colchicine Resistance; Inflammatory Bowel Disease 13

size1 :

0.05 mg

price1 :

540 USD

more info or order :

MyBioSource product webpage