MMP9 antibody | MyBioSource MBS535606 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MMP9 antibody

catalog :

MBS535606

quantity :

0.05 mg

price :

540 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535606

products type :

Antibody

products full name :

MMP9 antibody

products short name :

MMP9

products name syn :

Polyclonal MMP9; Anti-MMP9; 92kd gelatinase; MMP 9; MMP9; MMP -9; mmp9; 92 kd type iv collagenase; matrix metalloproteinase 9; gelatinase b

other names :

matrix metalloproteinase-9 preproprotein; Matrix metalloproteinase-9; matrix metalloproteinase-9; matrix metallopeptidase 9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB

products gene name :

MMP9

other gene names :

MMP9; MMP9; GELB; CLG4B; MMP-9; MANDP2; CLG4B; MMP-9; GELB

uniprot entry name :

MMP9_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

707

purity :

MMP9 antibody was purified by affinity chromatography.

form :

Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

IHC-P: 10 ug/ml

other info1 :

Biological Significance: Matrix metallopeptidase 9 (MMP9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is an enzyme that in humans is encoded by the MMP9 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakDaown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: MMP9 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Rabbit polyclonal MMP9 antibody

ncbi gi num :

74272287

ncbi acc num :

NP_004985

ncbi gb acc num :

NM_004994.2

uniprot acc num :

P14780

ncbi mol weight :

78,458 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Angiogenesis Pathway (198772); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); CXCR4-mediated Signaling Events Pathway (137910); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP9: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family. Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.24.35; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 20q13.12. Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region. Molecular Function: collagen binding; identical protein binding; protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity. Biological Process: positive regulation of keratinocyte migration; axon guidance; ossification; extracellular matrix organization and biogenesis; macrophage differentiation; positive regulation of apoptosis; proteolysis; collagen catabolic process; extracellular matrix disassembly; ephrin receptor signaling pathway; leukocyte migration; skeletal development; embryo implantation. Disease: Metaphyseal Anadysplasia 2

size1 :

0.05 mg

price1 :

540 USD

more info or order :

MyBioSource product webpage