ITGA4 antibody | MyBioSource MBS535463 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITGA4 antibody

catalog :

MBS535463

quantity :

0.05 mg

price :

540 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535463

products type :

Antibody

products full name :

ITGA4 antibody

products short name :

ITGA4

products name syn :

Polyclonal ITGA4; Anti-ITGA4; integrin alpha-4 subunit precursor; ITGA -4; ITGA 4; vla-4; itga4; integrin alpha-iv; integrin alpha-4; cd49d; ITGA4

other names :

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor), isoform CRA_a; Integrin alpha-4; integrin alpha-4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d

products gene name :

ITGA4

other gene names :

ITGA4; ITGA4; IA4; CD49D; CD49D

uniprot entry name :

ITA4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

1032

purity :

ITGA4 antibody was purified by affinity chromatography.

form :

Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

IHC-P: 10 ug/ml

other info1 :

Biological Significance: Integrin alpha 4 is also known as CD49D. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: ITGA4 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

products categories :

Signal Transduction

products description :

Rabbit polyclonal ITGA4 antibody

ncbi gi num :

119631392

ncbi acc num :

EAX10987.1

uniprot acc num :

P13612

ncbi mol weight :

21,536 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

ncbi summary :

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

uniprot summary :

ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 2q31.3. Cellular Component: cell surface; focal adhesion; membrane; plasma membrane; intercellular junction; external side of plasma membrane. Molecular Function: protein binding; fibronectin binding; metal ion binding; cell adhesion molecule binding. Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; regulation of immune response; heart development; cell-matrix adhesion; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; leukocyte tethering or rolling; blood coagulation; leukocyte migration

size1 :

0.05 mg

price1 :

540 USD

more info or order :

MyBioSource product webpage