GM-CSF antibody | MyBioSource MBS535397 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GM-CSF antibody

catalog :

MBS535397

quantity :

0.05 mg

price :

330 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535397

products type :

Antibody

products full name :

GM-CSF antibody

products short name :

GM-CSF

products name syn :

Polyclonal GM-CSF; Anti-GM-CSF; CSF-2; Granulocyte/Macrophage Colony-Stimulating Factor; pluripoietin-alpha; MGI-1GM; GM-CSF

other names :

granulocyte-macrophage colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim

products gene name :

GM-CSF

other gene names :

CSF2; CSF2; GMCSF; GMCSF; GM-CSF; CSF

uniprot entry name :

CSF2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human GM-CSF

sequence length :

144

form :

Lyophilized from PBS, pH 7.2. Reconstitute in sterile water at a concentration of >0.2 mg/ml.

concentration :

50ug per vial, lyophilized.

storage stability :

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

app notes :

ELISA: 0.5-2 ug/ml. Inhibition: 0.13-0.2 ug/ml. WB: 0.1-0.2 ug/ml

other info1 :

Biological Significance: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and Mouse molecules are species-specific and exhibit no cross-species reactivity.

other info2 :

Immunogen: GM-CSF antibody was raised in rabbit using highly pure recombinant human GM-CSF as the immunogen.

products categories :

Immunology; Purified Polyclonal Antibodies

products description :

Affinity purified Rabbit polyclonal GM-CSF antibody

ncbi gi num :

27437030

ncbi acc num :

NP_000749.2

ncbi gb acc num :

NM_000758.3

uniprot acc num :

P04141

ncbi mol weight :

14.5 kDa (predicted detection band MW)

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)

ncbi summary :

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

uniprot summary :

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

size1 :

0.05 mg

price1 :

330 USD

more info or order :

MyBioSource product webpage