Cytokeratin 8 +18 antibody | MyBioSource MBS535372 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cytokeratin 8 +18 antibody

catalog :

MBS535372

quantity :

0.1 mL

price :

430 USD

clonality :

polyclonal

host :

guinea pigs

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS535372

products type :

Antibody

products full name :

Cytokeratin 8 +18 antibody

products short name :

Cytokeratin 8 +18

products name syn :

Polyclonal Cytokeratin 8 +18; Anti-Cytokeratin 8 +18; Cytokeratin 8 + 18; Cytokeratin 8/18; Cytokeratin + 1 8; Cytokeratin + 1 -8; Keratin K8 + K18

other names :

cytokeratin 8 (279 AA), partial; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; keratin 8, type II; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8

other gene names :

KRT8; KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; CYK8; CK-8; K8

uniprot entry name :

K2C8_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Guinea Pig

reactivity :

Bovine, Frog, Human, Mouse, Rat, Syrian Hamster

sequence length :

279

specificity :

Bovine cytokeratin 8/18

purity :

Stabilized antiserum

form :

Supplied as whole antiserum with 0.09% NaN3.

concentration :

100ul Serum per vial

storage stability :

Store at 4 degree C.

tested application :

ELISA (EIA), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

app notes :

IHC-F: 1:100. IHC-P: 1:50. WB: 1:2,000

other info1 :

Biological Significance: Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin represents an excellent marker for the discrimination of specific subtypes of adenocarcinoma. Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Cytokeratin 8/8 antibody was raised in guinea pig using cytokeratin 8/18 filaments, reconstituted from purified bovine cytokeratins 8 and 18 as the immunogen.

products categories :

Cell Biology

products description :

Guinea Pig polyclonal Cytokeratin 8 +18 antibody

ncbi gi num :

30313

ncbi acc num :

CAA31376.1

uniprot acc num :

P05787

ncbi mol weight :

56,608 Da

ncbi pathways :

EGFR1 Signaling Pathway (198782); Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

ncbi summary :

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

uniprot summary :

K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; nuclear matrix; costamere; keratin filament; cytoplasm; intermediate filament; intercellular junction; Z disc; nucleus; sarcolemma. Molecular Function: protein binding; protein complex binding; structural molecule activity. Biological Process: tumor necrosis factor-mediated signaling pathway; viral reproduction; sarcomere organization; response to other organism; response to hydrostatic pressure. Disease: Cirrhosis, Familial

size1 :

0.1 mL

price1 :

430 USD

more info or order :

MyBioSource product webpage