antibody

UCP1 antibody

MBS535346

0.1 mg

705 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

UCP1 antibody

UCP1

Polyclonal UCP1; Anti-UCP1; UCP 1; Uncoupling Protein 1; UCP -1; UCP-1; UCP1

Uncoupling protein 1 (mitochondrial, proton carrier); Uncoupling protein 1 (Mitochondrial, proton carrier); mitochondrial brown fat uncoupling protein 1; uncoupling protein 1 (mitochondrial, proton carrier); Uncoupling protein 1 (Mitochondrial, proton carrier)

UCP1

UCP1; UCP1; UCP; SLC25A7

Q4KMT7_HUMAN

Polyclonal

IgG

Rabbit

To be determined by end-user

306

Murine

UCP1 antibody was purified by affinity chromatography.

Lyophilized from PBS with 0.1% BSA. Reconstitute in PBS to a concentration of 1 mg/ml.

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

ELISA: 1:10,000-1:100,000. IF: 2-20 ug/ml. WB: 1-10 ug/ml

Biological Significance: Uncoupling proteins (UCP1-5) are a family of mitochondria transport proteins that play a critical role in thermoregulatory heat production and maintenance of basal metabolic rate. UCP1 is predicted to contain 6 trans-membrane (TM) domains, a putative purine nucleotide-binding domain (PNBD) and three-mitochondrial energy transfer protein domains (ETPDs).

Immunogen: UCP1 antibody was raised in rabbit using a 12 amino acid peptide from mouse/rat UCP1 as the immunogen.

Nutrition & Metabolism; Purified Polyclonal Antibodies

Affinity purified Rabbit polyclonal UCP1 antibody

68532600

AAH98352.1

Q4KMT7

32,933 Da

Adipogenesis Pathway 198832!!Electron Transport Chain Pathway 198860!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!Metabolism Pathway 477135!!Mitochondrial Uncoupling Proteins Pathway 160963!!PPAR Signaling Pathway 83042!!PPAR Signaling Pathway 450!!Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway 105921!!The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway 477137

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

0.1 mg

705 USD