antibody

Neuromedin U antibody

MBS535285

0.05 mL

525 USD

polyclonal

rabbit

nonconjugated

human, rat, chicken

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

Antibody

Neuromedin U antibody

Neuromedin U

Polyclonal Neuromedin U; Anti-Neuromedin U

neuromedin U; Neuromedin-U; neuromedin-U; neuromedin U

NMU; NMU; NmU-25

NMU_HUMAN

Polyclonal

IgG1

Rabbit

Chicken, Rat

174

Porcine neuromedin U

Whole antiserum

Supplied as a lyophilized powder. Dissolve the antiserum in 50 - 100 ul distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% NaN3.

50ul, lyophilized

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin

IF-FITC: 1:1,000-1:1,500

Biological Significance: Neuromedin U is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Neuromedin U antibody was raised in rabbit using synthetic neuromedin U-8, porcine sequence, conjugated to BSA as the immunogen.

Neuroscience

Rabbit polyclonal Neuromedin U antibody

609013

CAA53619.1

P48645

19,741 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

NMU: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Belongs to the NmU family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q12. Cellular Component: extracellular region; terminal button. Molecular Function: neuromedin U receptor binding; receptor binding. Biological Process: regulation of smooth muscle contraction; gastric acid secretion; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; eating behavior; photoperiodism; digestion; positive regulation of hormone secretion; positive regulation of smooth muscle contraction; sensory perception of pain; signal transduction; positive regulation of synaptic transmission

0.05 mL

525 USD