catalog number :
MBS535235
products full name :
NET antibody
products short name :
NET
products name syn :
Polyclonal NET; Anti-NET; Norepinephrine Transporter
other names :
norepinephrine transporter; Sodium-dependent noradrenaline transporter; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; Norepinephrine transporter; NET; Solute carrier family 6 member 2
other gene names :
SLC6A2; SLC6A2; NET; NAT1; NET1; SLC6A5; NAT1; NET1; SLC6A5; NET
uniprot entry name :
SC6A2_HUMAN
reactivity :
To be determined by end-user
purity :
NET antibody was purified by affinity chromatography.
form :
Lyophilized from PBS with 0.1% BSA, and 0.05% NaN3. Reconstitute in 100 ul of PBS.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
ELISA: 1:10,000-1:100,000. IF: 2 ug/ml. IHC: 2 ug/ml. WB: 1-10 ug/ml
other info1 :
Biological Significance: Noradrenaline transporter or epinephrine transporter (NET or NTT1 or NAT1 or SLC6A2) gene (chromosome 16) encodes a protein of 617 aa (mouse 617 aa, ~94% identity), with 12-13 transmembrane domains, and cytoplasmic N and C-termini.
other info2 :
Immunogen: NET antibody was raised in rabbit using a 22 amino acid peptide of rat NET as the immunogen.
products categories :
Cancer; Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal NET antibody
ncbi acc num :
CAA62566.1
ncbi mol weight :
57,370 Da
ncbi pathways :
Monoamine Transport Pathway 198851!!Na+/Cl- Dependent Neurotransmitter Transporters Pathway 161070!!SLC-mediated Transmembrane Transport Pathway 119558!!Transmembrane Transport Of Small Molecules Pathway 106572!!Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway 119571
ncbi summary :
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]