antibody

Dopamine D2 Receptor antibody

MBS535201

0.1 mL

615 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Dopamine D2 Receptor antibody

Dopamine D2 Receptor

Polyclonal Dopamine D2 Receptor; Anti-Dopamine D2 Receptor; Dopamine D Receptor -2; Dopamine D Receptor 2; Dopamine D2 Receptor; D2R Anibody

D(2) dopamine receptor isoform short; D(2) dopamine receptor; D(2) dopamine receptor; dopamine receptor D2; Dopamine D2 receptor

DRD2; DRD2; D2R; D2DR

DRD2_HUMAN

Polyclonal

IgG

Rabbit

Human, Lobster, Squid, Crayfish

414

Rat

Neat Serum with 0.05% NaN3.

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

ELISA: 1:10,000-1:50,000. WB: 1:1,000-1:5,000

Biological Significance: Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. D2 is encoded by the Dopamine receptor D2 gene (DRD2), of which there are two forms. The D2Sh form is pre-synaptically situated, having modulatory functions and the D2Lh form may function as a classical post-synaptic receptor.

Immunogen: Dopamine D2 receptor antibody was raised in rabbit using an 11 amino acid peptide of rat D2R as the immunogen.

Neuroscience

Rabbit polyclonal Dopamine D2 Receptor antibody

17986270

NP_057658.2

NM_016574.3

P14416

50,847 Da

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amine Ligand-binding Receptors Pathway (106363); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cocaine Addiction Pathway (546258); Cocaine Addiction Pathway (546273); Dopamine Receptors Pathway (106366); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); G Alpha (i) Signalling Events Pathway (119550)

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: synaptic vesicle membrane; axon; endocytic vesicle; integral to plasma membrane; dendrite; postsynaptic density; acrosome; plasma membrane; dendritic spine; perikaryon; nerve terminal; lateral plasma membrane. Molecular Function: dopamine D2 receptor-like receptor activity; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein homodimerization activity; potassium channel regulator activity; protein heterodimerization activity; dopamine binding; drug binding. Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of dopamine uptake; prepulse inhibition; response to toxin; positive regulation of receptor internalization; regulation of phosphoprotein phosphatase activity; positive regulation of multicellular organism growth; thermoregulation; adult walking behavior; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; negative regulation of insulin secretion; protein localization; negative regulation of blood pressure; phosphatidylinositol metabolic process; response to drug; response to inactivity; response to light stimulus; positive regulation of neuroblast proliferation; cerebral cortex GABAergic interneuron migration; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; positive regulation of growth hormone secretion; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; negative regulation of cell proliferation; synaptogenesis; behavioral response to cocaine; adenohypophysis development; visual learning; feeding behavior; nerve-nerve synaptic transmission; circadian regulation of gene expression; response to axon injury; negative regulation of dopamine secretion; response to iron ion; negative regulation of cell migration; associative learning; grooming behavior; positive regulation of cytokinesis; negative regulation of protein secretion; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; striatum development; regulation of potassium ion transport; regulation of cAMP metabolic process; regulation of heart rate; response to amphetamine; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of dopamine uptake; auditory behavior; response to cocaine; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; axonogenesis; long-term memory; pigmentation; positive regulation of G-protein coupled receptor protein signaling pathway; release of sequestered calcium ion into cytosol; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway. Disease: Myoclonic Dystonia

0.1 mL

615 USD