antibody

Ceruloplasmin antibody

MBS535184

1 mL

255 USD

polyclonal

sheep

nonconjugated

human, mouse, rat

Antibody

Ceruloplasmin antibody

Ceruloplasmin

Polyclonal Ceruloplasmin; Anti-Ceruloplasmin

ceruloplasmin, partial; Ceruloplasmin; ceruloplasmin; ceruloplasmin (ferroxidase); Ferroxidase

CP; CP; CP-2

CERU_HUMAN

Polyclonal

Sheep

Horse, Mouse, Pig, Rabbit, Rat

4

Specific for human Ceruloplasmin. Negative cross-reactivity against: Cat, Chicken, Cow, Dog, Guinea Pig, Rabbit and Goat.

Ceruloplasmin antibody was purified by Ion exchange chromatography.

IgG Fraction supplied as a liquid in PBS, pH 7.4, with 0.1% Sodium Azide as a preservative.

5.0mg/ml

Store at 4 degree C, -20 degree C long term.

User optimized

Biological Significance: Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. Ceruloplasmin carries about 70% of the total copper in human plasma while albumin carries about 15%.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Ceruloplasmin antibody was raised in sheep using human ceruloplasmin purified from plasma as the immunogen.

Nutrition & Metabolism

Sheep polyclonal Ceruloplasmin antibody

1731685

BAA08085.1

P00450

HIF-1-alpha Transcription Factor Network Pathway (138045); Iron Uptake And Transport Pathway (187191); Metal Ion SLC Transporters Pathway (161066); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. Protein type: Secreted, signal peptide; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Secreted; EC 1.16.3.1. Chromosomal Location of Human Ortholog: 3q23-q25. Cellular Component: extracellular space; lysosomal membrane; extracellular region. Molecular Function: ferroxidase activity; copper ion binding; chaperone binding. Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport. Disease: Aceruloplasminemia

1 mL

255 USD