catalog number : 
MBS535183
products full name : 
Vimentin antibody
products short name : 
Vimentin
products name syn : 
Polyclonal Vimentin; Anti-Vimentin
other names : 
vimentin; Vimentin; vimentin; vimentin
other gene names : 
VIM; VIM; HEL113; CTRCT30
uniprot entry name : 
VIME_HUMAN
reactivity : 
Bovine, Human, Mouse
specificity : 
Bovine vimentin
purity : 
Stabilized antiserum
form : 
Suppleid as antierum with 0.09% NaN3.
storage stability : 
Store at 4 degree C.
tested application : 
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
app notes : 
IHC-F: 1:100. IHC-P: 1:100. WB: 1:2,000
other info1 : 
Biological Significance: Vimentin is a member of the intermediate filament family of proteins that is especially found in connective tissue. Intermediate filaments are an important structural feature of eukaryotic cells. They, along with microtubules and actin microfilaments, make up the cytoskeleton. Although most intermediate filaments are stable structures, in fibroblasts, vimentin exists as a dynamic structure. This filament is used as a marker for mesodermally derived tissues, and as such can be used as an immunohistochemical marker for sarcomas.
other info2 : 
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.  Immunogen: Vimentin antibody was raised in guinea pig using vimentin purified from calf lens as the immunogen.
products categories : 
Cell Biology
products description : 
Guinea Pig polyclonal Vimentin antibody
ncbi acc num : 
NP_003371.2
ncbi gb acc num : 
NM_003380.3
ncbi mol weight : 
53,652 Da
ncbi pathways : 
Alpha6-Beta4 Integrin Signaling Pathway  198807!!Apoptosis Pathway  105648!!Apoptotic Cleavage Of Cellular Proteins Pathway  105678!!Apoptotic Execution  Phase Pathway  105677!!Aurora B Signaling Pathway  138080!!Caspase Cascade In Apoptosis Pathway  137974!!Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway  105679!!Epstein-Barr Virus Infection Pathway  585562!!Epstein-Barr Virus Infection Pathway  587115!!MicroRNAs In Cancer Pathway  852705
ncbi summary : 
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]