antibody

Cytokeratin antibody

MBS535079

0.1 mL

430 USD

polyclonal

guinea pigs

nonconjugated

human, mouse

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Cytokeratin antibody

Cytokeratin

Polyclonal Cytokeratin; Anti-Cytokeratin; Keratin

cytokeratin; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; keratin 8, type II; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8

KRT8; KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; CYK8; CK-8; K8

K2C8_HUMAN

Polyclonal

Guinea Pig

Human, Mouse

279

Human cytokeratin

Stabilized antiserum

Supplied as whole antiserum with 0.09% NaN3.

Store at 4 degree C.

Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

IHC-F: 1:100. IHC-P: 1:50. WB: 1:2,000

Biological Significance: Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin represents an excellent marker for the discrimination of specific subtypes of adenocarcinoma.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Cytokeratin antibody was raised in guinea pig using synthetic peptides of human keratins as the immunogen.

Cell Biology

Guinea Pig polyclonal Cytokeratin antibody

1419564

CAA67203.1

P05787

56,608 Da

EGFR1 Signaling Pathway (198782); Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; costamere; nuclear matrix; keratin filament; cytoplasm; intermediate filament; intercellular junction; nucleus; Z disc; sarcolemma. Molecular Function: protein binding; protein complex binding; structural molecule activity. Biological Process: tumor necrosis factor-mediated signaling pathway; viral reproduction; sarcomere organization; response to other organism; response to hydrostatic pressure. Disease: Cirrhosis, Familial

0.1 mL

430 USD