antibody

Aldehyde Dehydrogenase antibody

MBS534874

1 mL

185 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunoprecipitation, enzyme immunoassay

Antibody

Aldehyde Dehydrogenase antibody

Aldehyde Dehydrogenase

Polyclonal Aldehyde Dehydrogenase; Anti-Aldehyde Dehydrogenase; ALDH1; Aldehyde dehydrogenase [NAD(P)+] 1; ALD5; ALD2

aldehyde dehydrogenase; Aldehyde dehydrogenase, mitochondrial; aldehyde dehydrogenase, mitochondrial; aldehyde dehydrogenase 2 family (mitochondrial); ALDH class 2; ALDH-E2; ALDHI

ALDH2; ALDH2; ALDM; ALDHI; ALDH-E2; ALDM

ALDH2_HUMAN

Polyclonal

Rabbit

Saccharomyces cerevisiae ALDH

517

Aldehyde Dehydrogenase antibody was purified by ion exchange chromatography followed by dialysis.

Supplied as a liquid in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, and 0.01% NaN3.

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

ELISA: 1:5,000-1:20,000. IP: 1:100. WB: 1:500-1:2,000

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Aldehyde dehydrogenase antibody was raised in rabbit using aldehyde dehydrogenase isolated from yeast as the immunogen.

Proteases, Inhibitors, & Enzymes

Rabbit polyclonal Aldehyde Dehydrogenase antibody

178390

AAA51693.1

P05091

50,989 Da

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Ascorbate And Aldarate Metabolism Pathway (82932); Ascorbate And Aldarate Metabolism Pathway (293); Biological Oxidations Pathway (105698); Biosynthesis Of Antibiotics Pathway (1144997); Ethanol Oxidation Pathway (105715); Fatty Acid Omega Oxidation Pathway (198915); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296)

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]. Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial; EC 1.2.1.3; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Oxidoreductase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerolipid; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tryptophan. Chromosomal Location of Human Ortholog: 12q24.2. Cellular Component: mitochondrial matrix. Molecular Function: aldehyde dehydrogenase (NAD) activity; electron carrier activity; aldehyde dehydrogenase [NAD(P)+] activity. Biological Process: synaptic transmission; ethanol catabolic process; xenobiotic metabolic process; alcohol metabolic process; carbohydrate metabolic process; ethanol oxidation; neurotransmitter biosynthetic process. Disease: Alcohol Sensitivity, Acute

1 mL

185 USD