product summary
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company name :
MyBioSource
product type :
antibody
product name :
p63 antibody
catalog :
MBS534830
quantity :
0.25 mg
price :
390 USD
clonality :
polyclonal
host :
sheep
conjugate :
nonconjugated
reactivity :
human
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS534830
products type :
Antibody
products full name :
p63 antibody
products short name :
p63
products name syn :
Polyclonal p63; Anti-p63; p 63; p -63; p63; p63 MAPK; p63 MAP Kinase
other names :
p63; M-phase inducer phosphatase 2; M-phase inducer phosphatase 2; cell division cycle 25B; Dual specificity phosphatase Cdc25B
products gene name :
p63
other gene names :
CDC25B; CDC25B; CDC25HU2
uniprot entry name :
MPIP2_HUMAN
clonality :
Polyclonal
host :
Sheep
reactivity :
To be determined by end-user
sequence length :
566
form :
0.15M PBS buffer, pH 7.5
concentration :
Typically 1-5 mg/ml
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.
tested application :
User optimized
other info1 :
Biological Significance: Tumor protein p63 also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene. Tumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium.
other info2 :
Immunogen: p63 antibody was raised in sheep using p63 MAP kinase as the immunogen.
products categories :
Cancer
products description :
Sheep polyclonal p63 antibody
ncbi gi num :
243486
ncbi acc num :
AAB21139.1
uniprot acc num :
P30305
ncbi mol weight :
67,241 Da
ncbi pathways :
Aurora A Signaling Pathway (137925); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cyclin A/B1 Associated Events During G2/M Transition Pathway (105802); Cyclin A:Cdk2-associated Events At S Phase Entry Pathway (105783); Cyclin B2 Mediated Events Pathway (105804); DNA Damage-induced Cell Cycle Checkpoints Pathway (1084767)
ncbi summary :
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
uniprot summary :
CDC25B: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described. Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol. Molecular Function: protein binding; protein tyrosine phosphatase activity; protein kinase binding. Biological Process: positive regulation of cytokinesis; mitosis; cell division; positive regulation of protein kinase activity; positive regulation of cell proliferation; mitotic cell cycle; positive regulation of mitotic cell cycle; G2/M transition of mitotic cell cycle; oocyte maturation; protein amino acid phosphorylation; female meiosis I
size1 :
0.25 mg
price1 :
390 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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