antibody

Collagen Type X antibody

MBS534784

0.5 mL

865 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, immunoprecipitation

Antibody

Collagen Type X antibody

Collagen Type X

Polyclonal Collagen Type X; Anti-Collagen Type X; Collagen; Type X Collagen

collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia); Collagen alpha-1(X) chain; collagen alpha-1(X) chain; collagen, type X, alpha 1

COL10A1; COL10A1

COAA1_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

680

Neat Serum with no preservatives.

Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles

Immunoprecipitation (IP), Western Blot (WB)

Biological Significance: Collagen alpha-1(X) chain is a protein that in humans is encoded by the COL10A1 gene. This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer.

Immunogen: Collagen type X antibody was raised in rabbit using purified type X collagen from rat chondrosarcoma cells as the immunogen. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Cancer

Rabbit polyclonal Collagen Type X antibody

119568625

EAW48240.1

Q03692

66,158 Da

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Senescence And Autophagy Pathway (198780)

This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]

COL10A1: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. Defects in COL10A1 are the cause of Schmid type metaphyseal chondrodysplasia (SMCD). SMCD is a dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6q21-q22. Cellular Component: proteinaceous extracellular matrix; collagen; endoplasmic reticulum lumen; extracellular region; cell cortex. Molecular Function: metal ion binding. Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cartilage development; skeletal development; endochondral ossification. Disease: Metaphyseal Chondrodysplasia, Schmid Type

0.5 mL

865 USD