antibody

phospho-Phospholamban antibody

MBS534685

0.1 mg

700 USD

polyclonal

rabbit

nonconjugated

Antibody

phospho-Phospholamban antibody

Phospholamban

Polyclonal phospho-Phospholamban; Anti-phospho-Phospholamban; pPhospholamban; Phosphorylated Phospholamban

phospholamban; Cardiac phospholamban; cardiac phospholamban; phospholamban

PLN; PLN; PLB; CMD1P; CMH18; PLB; PLB

PPLA_HUMAN

Polyclonal

IgG

Rabbit

Bovine, Dog, Mouse, Rat

52

human

phospho-Phospholamban antibody was purified by affinity chromatography.

100mM Tris-glycine, pH 7.4, with 150mM NaCl, 0.05% NaN3 and 30% glycerol.

Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles

Western Blot (WB)

Biological Significance: Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Phospho-Phospholamban antibody was raised in rabbit using a synthetic peptide conjugated to KLH, corresponding to amino acids 14-25 of human cardiac phospholamban (RA[pS]TIEMPQQAR-C) as the immunogen.

Proteases, Inhibitors, & Enzymes

Rabbit polyclonal phospho-Phospholamban antibody

190019

AAA60109.1

P26678

6,109 Da

Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285!!Integrated Pancreatic Cancer Pathway 711360!!Ion Channel Transport Pathway 187193!!Ion Transport By P-type ATPases Pathway 187194

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]

0.1 mg

700 USD