Adipophilin antibody | MyBioSource MBS534652 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Adipophilin antibody

catalog :

MBS534652

quantity :

0.1 mL

price :

535 USD

clonality :

polyclonal

host :

guinea pigs

conjugate :

nonconjugated

reactivity :

human, rat, dog, cow

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS534652

products type :

Antibody

products full name :

Adipophilin antibody

products short name :

Adipophilin

products name syn :

Polyclonal Adipophilin; Anti-Adipophilin

other names :

adipophilin, partial; Perilipin-2; perilipin-2; perilipin 2; Adipophilin; Adipose differentiation-related protein; ADRP

other gene names :

PLIN2; PLIN2; ADFP; ADRP; ADFP; ADRP

uniprot entry name :

PLIN2_HUMAN

clonality :

Polyclonal

host :

Guinea Pig

reactivity :

Bovine, Dog, Human, Mouse, Rat

sequence length :

437

specificity :

Human adipophilin

purity :

Whole antiserum

form :

Supplied as whole antiserum with 0.09% NaN3.

storage stability :

Store at 4 degree C.

tested application :

Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

app notes :

IHC-F: 1:100. IHC-P: 1:100. WB: 1:2,000. Adipocytes are negative. Also positively stained are lipid-storing CD 68-positive macrophages.

other info1 :

Biological Significance: Adipophilin / ADRP (a member of the PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al.; for review see e.g. Targett-Adams et al.); inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Adipophilin antibody was raised in guinea pig using a synthetic peptide corresponding to residues 1-29 of the N-terminus of human and murine adipophilin as the immunogen.

products categories :

Cancer

products description :

Guinea Pig polyclonal Adipophilin antibody

products references :

Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones; Jie Donga, Tammy Tonga, Amanda M. Reynadoa, Jeffrey M. Rosenb, Shixia Huangb, Yi Li (Developmental Biology: Volume: 346 Issue: 2 Page: 196-203 DOI: 10.1016/j.ydbio.2010.07.027)

ncbi gi num :

1806040

ncbi acc num :

CAA65989.1

uniprot acc num :

Q99541

ncbi mol weight :

48,075 Da

ncbi pathways :

Adipogenesis Pathway (198832); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

ncbi summary :

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

uniprot summary :

perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family. Protein type: Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 9p22.1. Cellular Component: endoplasmic reticulum; plasma membrane; extracellular region; lipid particle; cytosol; nucleus. Biological Process: long-chain fatty acid transport; response to drug; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance

size1 :

0.1 mL

price1 :

535 USD

more info or order :

MyBioSource product webpage