antibody

Cathepsin B antibody

MBS534639

1 mL

450 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Cathepsin B antibody

Cathepsin B

Polyclonal Cathepsin B; Anti-Cathepsin B

cathepsin B; Cathepsin B; cathepsin B; cathepsin B; APP secretase; APPS

CTSB; CTSB; APPS; CPSB; CPSB; APPS

CATB_HUMAN

Polyclonal

IgG

Rabbit

Human

339

Purified IgG fraction supplied in PBS with 0.05% NaN3.

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Western Blot (WB)

Biological Significance: Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Cathepsin B antibody was raised in rabbit using cathepsin B (human Liver) as the immunogen.

Proteases, Inhibitors, & Enzymes

Rabbit polyclonal Cathepsin B antibody

291888

AAC37547.1

P07858

37,822 Da

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Immune System Pathway (106386); Innate Immune System Pathway (106387)

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Protein type: Motility/polarity/chemotaxis; EC 3.4.22.1; Autophagy; Protease. Chromosomal Location of Human Ortholog: 8p22. Cellular Component: extracellular space; mitochondrion; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; melanosome; extracellular region; nucleolus; intracellular. Molecular Function: peptidase activity; collagen binding; protein binding; proteoglycan binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: regulation of apoptosis; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis involved in cellular protein catabolic process; epithelial cell differentiation; regulation of catalytic activity; toll-like receptor signaling pathway; innate immune response; decidualization; proteolysis

1 mL

450 USD