catalog number :
MBS534598
products full name :
Thyroglobulin antibody
products short name :
Thyroglobulin
products name syn :
Polyclonal Thyroglobulin; Anti-Thyroglobulin; hTg; Tg
other names :
thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin
other gene names :
TG; TG; TGN; AITD3; Tg
uniprot entry name :
THYG_HUMAN
reactivity :
To be determined by end-user
specificity :
Human thyroglobulin
form :
Supplied as whole antiserum containing 0.09% NaN3. Dilute in PBS immediately before use.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
IHC: 1:50-1:100
other info1 :
Biological Significance: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid. Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Thyroglobulin antibody was raised in rabbit using thyroblogulin Isolated from human thyroid as the immunogen.
products categories :
Hormones & Steroids
products description :
Rabbit polyclonal Thyroglobulin antibody
ncbi acc num :
CAA29104.1
ncbi mol weight :
298,383 Da
ncbi pathways :
Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Thyroxine (Thyroid Hormone) Production Pathway 920992
ncbi summary :
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]