catalog number :
MBS534595
products full name :
Grp78 antibody
products short name :
Grp78
products name syn :
Polyclonal Grp78; Anti-Grp78; Grp 78; Grp -78; Grp78
other names :
GRP78, partial; 78 kDa glucose-regulated protein; 78 kDa glucose-regulated protein; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
products gene name :
Grp78
other gene names :
HSPA5; HSPA5; BIP; MIF2; GRP78; HEL-S-89n; GRP78; GRP-78; BiP
uniprot entry name :
GRP78_HUMAN
reactivity :
Mouse, Rat, Bovine, eumycota, Hamster, Non-Human Primate, Rabbit, Xenopus
purity :
Grp78 antibody antibody was purified by Protein a affinity chromatography.
form :
Neat Serum with no preservatives.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Western Blot (WB)
other info1 :
Biological Significance: Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER), that binds newly-synthesized proteins as they are translocated into the ER and maintains them in a state competent for subsequent folding and oligomerization.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Grp78 antibody was raised in rabbit using a synthetic peptide corresponding to the sequence near the C-terminus of rat Grp78 (BiP) as the immunogen.
products categories :
Cancer
products description :
Rabbit polyclonal Grp78 antibody
ncbi acc num :
AAA52614.1
ncbi mol weight :
72,333 Da
ncbi pathways :
ATF6-alpha Activates Chaperone Genes Pathway 530770!!ATF6-alpha Activates Chaperones Pathway 105905!!Adaptive Immune System Pathway 366160!!Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway 366163!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Cellular Response To Heat Stress Pathway 1127553!!Cellular Responses To Stress Pathway 645258!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Hemostasis Pathway 106028
ncbi summary :
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]