LDL Receptor antibody (biotin) | MyBioSource MBS534421 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LDL Receptor antibody (biotin)

catalog :

MBS534421

quantity :

0.25 mL

price :

550 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS534421

products type :

Antibody

products full name :

LDL Receptor antibody (biotin)

products short name :

LDL

products name syn :

Polyclonal LDL Receptor; Anti-LDL Receptor; Low Density Lipoprotein Receptor

other names :

low-density lipoprotein receptor isoform 2; Low-density lipoprotein receptor; low-density lipoprotein receptor; low density lipoprotein receptor

products gene name :

LDL

other gene names :

LDLR; LDLR; FH; FHC; LDLCQ2; LDL receptor

uniprot entry name :

LDLR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human LDL receptor

sequence length :

858

purity :

Immunoaffinity chromatography

form :

PBS with penicillin/streptomycin preservative

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC/FACS)

app notes :

FC: 1:10

other info1 :

Biological Significance: Low-density lipoprotein (LDL) is one of the five major groups of lipoproteins, which in order of size, largest to smallest, are chylomicrons, VLDL, IDL, LDL and HDL, that enable lipids like cholesterol and triglycerides to be transported within the water-based bloodstream. Blood tests typically report LDL-C, the amount of cholesterol contained in LDL. In clinical context, mathematically calculated estimates of LDL-C are commonly used to estimate how much low density lipoproteins are driving progression of atherosclerosis. Direct LDL measurements are also available.

other info2 :

Tag/Conjugate: Biotin. Immunogen: LDL receptor antibody (biotin) was raised in rabbit using a specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the LDL receptor extracellular domain as the immunogen.

products categories :

Cardiac Markers; Conjugated Polyclonal Antibodies

products description :

Rabbit polyclonal LDL Receptor antibody (biotin) conjugated

ncbi gi num :

307775412

ncbi acc num :

NP_001182727.1

ncbi gb acc num :

NM_001195798.1

uniprot acc num :

P01130

ncbi mol weight :

82,255 Da

ncbi pathways :

Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Chylomicron-mediated Lipid Transport Pathway (106157); DNA Damage Response (only ATM Dependent) Pathway (198827); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); LDL-mediated Lipid Transport Pathway (106159); Lipid Digestion, Mobilization, And Transport Pathway (106111)

ncbi summary :

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

uniprot summary :

LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: Golgi apparatus; cell surface; membrane; integral to plasma membrane; lysosome; early endosome; late endosome; plasma membrane; endosome membrane; coated pit; receptor complex; external side of plasma membrane. Molecular Function: very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding. Biological Process: cholesterol metabolic process; phototransduction, visible light; lipoprotein catabolic process; receptor-mediated endocytosis; cholesterol transport; viral reproduction; cholesterol absorption; endocytosis; lipoprotein metabolic process; cholesterol homeostasis; phospholipid transport; lipid metabolic process; retinoid metabolic process. Disease: Hypercholesterolemia, Familial

size1 :

0.25 mL

price1 :

550 USD

more info or order :

MyBioSource product webpage