catalog number :
MBS534296
products full name :
Luteinizing Hormone beta antibody
products short name :
Luteinizing Hormone beta
products name syn :
Polyclonal Luteinizing Hormone beta; Anti-Luteinizing Hormone beta; LH
other names :
luteinizing hormone beta subunit (LHbeta), partial; Lutropin subunit beta; lutropin subunit beta; luteinizing hormone beta polypeptide; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta
other gene names :
LHB; LHB; CGB4; HH23; hLHB; LSH-B; Lutropin beta chain; LH-B; LSH-B; LSH-beta
uniprot entry name :
LSHB_HUMAN
reactivity :
Specific for beta hLH
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Biological Significance: Luteinizing hormone (LH) is a hormone produced by the anterior pituitary gland. In females, an acute rise of LH called the LH surge triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell-stimulating hormone (ICSH) it stimulates Leydig cell production of testosterone.
other info2 :
Immunogen: Luteinizing hormone antibody was raised in rabbit using LH beta-KLH as the immunogen.
products categories :
Hormones & Steroids
products description :
Rabbit polyclonal Luteinizing Hormone beta antibody
ncbi acc num :
AAD14960.1
ncbi mol weight :
15,345 Da
ncbi pathways :
Androgen Biosynthesis Pathway (106154); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Glycoprotein Hormones Pathway (160989); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502); Hormone Ligand-binding Receptors Pathway (106369); Metabolism Pathway (477135)
ncbi summary :
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
uniprot summary :
LHB: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Defects in LHB are a cause of hypogonadism LHB-related (HGON-LHB). Hypogonadism is characterized by infertility and pseudohermaphroditism. Belongs to the glycoprotein hormones subunit beta family. Protein type: Secreted; Secreted, signal peptide; Hormone. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: extracellular region. Molecular Function: hormone activity; receptor binding. Biological Process: progesterone biosynthetic process; cellular protein metabolic process; cell-cell signaling; male gonad development; peptide hormone processing; signal transduction. Disease: Fertile Eunuch Syndrome