alpha 1 Trypsin antibody | MyBioSource MBS534237 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

alpha 1 Trypsin antibody

catalog :

MBS534237

quantity :

0.1 mg

price :

625 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS534237

products type :

Antibody

products full name :

alpha 1 Trypsin antibody

products short name :

alpha 1 Trypsin

products name syn :

Polyclonal alpha 1 Trypsin; Anti-alpha 1 Trypsin; alpha Trypsin-1; A1AT; alpha Trypsin 1; alpha 1 antiproteinase; alpha 1 Trypsin; AAT; alpha 1 antitrypsin; alpha 1 protease inhibitor antibod

other names :

alpha-1-antitrypsin; Alpha-1-antitrypsin; alpha-1-antitrypsin; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1

other gene names :

SERPINA1; SERPINA1; PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT; AAT; PI; SPAAT

uniprot entry name :

A1AT_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

human alpha-1-trypsin

sequence length :

418

purity :

Alpha 1 Trypsin antibody was purified by ion exchange chromatography followed by dialysis.

form :

Lyophilized from 0.02M K3PO4, pH 7.2, with 0.15M NaCl and 0.01% NaN3.

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: 1:20,000-1:100,000. WB: 1:2,000-1:10,000

other info1 :

Biological Significance: Alpha 1-Antitrypsin or alpha1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Alpha-1 trypsin antibody was raised in goat using human alpha-1-anti-trypsin as the immunogen.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Goat polyclonal alpha 1 Trypsin antibody

ncbi gi num :

177831

ncbi acc num :

AAB59495.1

uniprot acc num :

P01009

ncbi mol weight :

34,755 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA1 Transcription Factor Network Pathway (137979); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding. Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus. Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive

size1 :

0.1 mg

price1 :

625 USD

more info or order :

MyBioSource product webpage