product summary
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company name :
MyBioSource
product type :
antibody
product name :
5-Lipoxygenase antibody
catalog :
MBS534195
quantity :
0.1 ml
price :
675 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, rat
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS534195
products type :
Antibody
products full name :
5-Lipoxygenase antibody
products short name :
5-Lipoxygenase
products name syn :
Polyclonal 5 Lipoxygenase; Anti-5 Lipoxygenase; -Lipoxygenase -5; -Lipoxygenase 5; 5-Lipoxygenase
other names :
5-lipoxygenase, partial; Arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase
other gene names :
ALOX5; ALOX5; 5-LO; 5LPG; LOG5; 5-LOX; LOG5; 5-LO; 5-lipoxygenase
uniprot entry name :
LOX5_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Rat
sequence length :
50
specificity :
Human 5-lipoxygenase
form :
10mM HEPES, pH 7.5, with 150mM NaCl, 100 ug/ml BSA and 50% Glycerol.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -80 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Western Blot (WB)
other info1 :
Biological Significance: 5-lipoxygenase (5-LO) catalyzes the formation of 5(S)-HpETE from arachidonic acid and its subsequent conversion to leukotriene A4. It is localized in the cytosol of resting human and rat peripheral blood neutrophils, whereas it is found in the nucleus in rat basophilic leukemia cells and human alveolar macrophages. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85 kDa cPLA2.
other info2 :
Immunogen: 5 Lipoxygenase antibody was raised in rabbit using phosphopeptide corresponding to amino acid residues surrounding the phosphoserine 523 of human 5-lipoxygenase (5-LO) as the immunogen.
products categories :
Proteases, Inhibitors, Purified Polyclonal Antibodies
products description :
Affinity purified Rabbit polyclonal 5-Lipoxygenase antibody
ncbi gi num :
187167
ncbi acc num :
AAA63212.1
uniprot acc num :
P09917
ncbi mol weight :
56,291 Da
ncbi pathways :
Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553!!Arachidonic Acid Metabolism Pathway 366!!Eicosanoid Synthesis Pathway 198888!!IL-5 Signaling Pathway 198770!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Ovarian Steroidogenesis Pathway 790011!!Ovarian Steroidogenesis Pathway 795173
ncbi summary :
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
size :
0.1 ml
price :
675 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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