catalog number :
MBS534137
products full name :
PDGF antibody
products short name :
PDGF
products name syn :
Polyclonal PDGF; Anti-PDGF; PDGF-BB; PDGF-AB; PDGF-AA; Platelet Derived Growth Factor
other names :
platelet-derived growth factor A-chain, partial; Platelet-derived growth factor subunit A; platelet-derived growth factor subunit A; platelet-derived growth factor alpha polypeptide; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
products gene name :
PDGF
other gene names :
PDGFA; PDGFA; PDGF1; PDGF-A; PDGF1; PDGF subunit A
uniprot entry name :
PDGFA_HUMAN
reactivity :
Bovine, Mouse, Pig
purity :
PDGF antibody was purified by DEAE chromatgraphy.
form :
Affi-Gel Blue purified protein supplied in 0.1M tris-glycine, pH 7.0.
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
Western Blot (WB)
other info1 :
Biological Significance: Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation.
other info2 :
Immunogen: PDGF antibody was raised in goat using purified human PDGF-AB as the immunogen.
products categories :
Cytokines & Growth Factors
products description :
Goat polyclonal PDGF antibody
ncbi acc num :
AAB26566.1
ncbi mol weight :
14-16 kDa (predicted detection band MW)
ncbi pathways :
Adaptive Immune System Pathway 366160!!Ceramide Signaling Pathway 138023!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232!!Constitutive Signaling By Aberrant PI3K In Cancer Pathway 685535!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550
ncbi summary :
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]