catalog number :
MBS534129
products full name :
Calbindin antibody (D28K)
products short name :
Calbindin
products name syn :
Polyclonal Calbindin (D28K); Anti-Calbindin (D28K); D 28K; CAB27; CALB1; CALB; Neuronal Marker; Calbindin D28; D28K; CALB 1; Calbindin 1 28kDa
other names :
calbindin; Calbindin; calbindin; calbindin 1, 28kDa; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type
other gene names :
CALB1; CALB1; CALB; D-28K; CAB27
uniprot entry name :
CALB1_HUMAN
reactivity :
Chicken, Fish, Human, Monkey, Mouse, Rat Reacts with Calbindin D-28K from Human, Monkey, Rat, Mouse, Chicken, and Fish
specificity :
Rat calbindin
form :
Supplied as a lyophilized powder
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -80 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
IHC: 1:10,000. WB: 1:1,000
other info1 :
Biological Significance: Calbindin D28k is a member of a large family of intracellular calcium binding proteins, containing EF hand calcium binding motifs, and related to calmodulin and troponin C. The biological roles of Calbindin D28k include calcium regulation and calcium dependent signalling in neurons and during development. Decreases in Calbindin D28k abundance, or loss of Calbindin D28k immunoreactivity, is found in models of neurological disorders such as epilepsy, and in neurodegenerative diseases. Calbindin antibody is often used as a marker for cerebellum Purkinje cells.
other info2 :
Immunogen: Calbindin antibody (D28K) was raised in rabbit using recombinant rat Calbindin D-28K as the immunogen.
products categories :
Nutrition & Metabolism
products description :
Rabbit polyclonal Calbindin antibody (D28K)
ncbi acc num :
NP_004920.1
ncbi gb acc num :
NM_004929.2
ncbi mol weight :
23,609 Da
ncbi pathways :
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276
ncbi summary :
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]