catalog number :
MBS534113
products full name :
VMAT2 antibody
products short name :
VMAT2
products name syn :
Polyclonal VMAT2; Anti-VMAT2; Synaptic Vesicle Monoamine Transporter 2; VMAT2; VMAT-2; VMAT 2; Vesicular Monoamine Transporter 2
other names :
vesicular monoamine transporter; Synaptic vesicular amine transporter; synaptic vesicular amine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2
products gene name :
VMAT2
other gene names :
SLC18A2; SLC18A2; SVAT; SVMT; VAT2; VMAT2; SVMT; VMAT2; VAT2
uniprot entry name :
VMAT2_HUMAN
reactivity :
Chicken, Dog, Frog, Guinea Pig, Hamster, Human, Mouse, Rat
form :
Supplied as a lyophilized powder. Dissolve the antiserum in 50 - 100 ul distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% NaN3.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunofluorescence (IF)
app notes :
IF-FITC: 1:800-1:1,200
other info1 :
Biological Significance: The vesicular monoamine transporter 2 (VMAT2) also known as solute carrier family 18 member 2 (SLC18A2) is a protein that in humans is encoded by the SLC18A2 gene. VMAT2 is an integral membrane protein that acts to transport monoamines?particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine?from cellular cytosol into synaptic vesicles.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: VMAT2 antibody was raised in rabbit using a synthetic peptide from C-terminus of rat VMAT2 conjugated to BSA as the immunogen.
products categories :
Neuroscience
products description :
Rabbit polyclonal VMAT2 antibody
ncbi acc num :
CAA50489.1
ncbi mol weight :
22,980 Da
ncbi pathways :
Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Cocaine Addiction Pathway 546258!!Cocaine Addiction Pathway 546273!!Dopamine Neurotransmitter Release Cycle Pathway 106523!!Dopaminergic Synapse Pathway 469199!!Dopaminergic Synapse Pathway 469185!!Na+/Cl- Dependent Neurotransmitter Transporters Pathway 161070
ncbi summary :
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]