DKK1 antibody | MyBioSource MBS533843 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DKK1 antibody

catalog :

MBS533843

quantity :

0.1 mL

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H2

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS533843

products type :

Antibody

products full name :

DKK1 antibody

products short name :

DKK1

products name syn :

Monoclonal DKK1; Anti-DKK1; Dickkopt-1; DKK-1; hdkk-1; DKK 1; hdkk1; Dickkopf-related protein-1; dkk1; DKK1; SK

other names :

dickkopf-related protein 1; Dickkopf-related protein 1; dickkopf-related protein 1; dickkopf WNT signaling pathway inhibitor 1; SK

products gene name :

DKK1

other gene names :

DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1

uniprot entry name :

DKK1_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

2H2

host :

Mouse

reactivity :

Human

sequence length :

266

form :

Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.

storage stability :

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: 1:10,000. WB: 1:500-1:2000

other info1 :

Biological Significance: Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway.

other info2 :

Immunogen: DKK1 antibody was raised in Mouse using a purified recombinant fragment of DKK1 expressed in E Coli as the immunogen.

products categories :

Differentiation & Development

products description :

Mouse monoclonal DKK1 antibody

ncbi gi num :

7110719

ncbi acc num :

NP_036374.1

ncbi gb acc num :

NM_012242.2

uniprot acc num :

O94907

ncbi mol weight :

28,672 Da

ncbi pathways :

Cardiac Progenitor Differentiation Pathway (712094); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); Diseases Of Signal Transduction Pathway (1183518); Presenilin Action In Notch And Wnt Signaling Pathway (137914); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516)

ncbi summary :

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

uniprot summary :

DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: extracellular space; early endosome membrane; extracellular region; plasma membrane. Molecular Function: signal transducer activity; protein binding; receptor antagonist activity; growth factor activity; low-density lipoprotein receptor binding. Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; response to retinoic acid; negative regulation of Wnt receptor signaling pathway; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; mesoderm formation; negative regulation of mesodermal cell fate specification; hair follicle development; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis

size1 :

0.1 mL

price1 :

395 USD

more info or order :

MyBioSource product webpage