Endostatin antibody | MyBioSource MBS533678 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Endostatin antibody

catalog :

MBS533678

quantity :

0.1 mg

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

KT58

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS533678

products type :

Antibody

products full name :

Endostatin antibody

products short name :

Endostatin

products name syn :

Monoclonal Endostatin; Anti-Endostatin

other names :

endostatin variant, partial; Collagen alpha-1(XVIII) chain; collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1

other gene names :

COL18A1; COL18A1; KS; KNO; KNO1

uniprot entry name :

COIA1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

KT58

host :

Mouse

sequence length :

102

specificity :

Human

purity :

Endostatin antibody was purified by Protein A chromatography.

form :

Supplied in PBS containing 0.1% sodium azide as a preservative

concentration :

1 mg/ml

storage stability :

Store at 4 degree C for up to 1 month. For long term storage, aliquot and store at -20 to -80 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA)

app notes :

ELISA: 1 ug/ml

other info1 :

Biological Significance: Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF basic.

other info2 :

Biohazard Information: This product contains sodium azide which is hazardous. Immunogen: Endostatin antibody was raised in Mouse using recombinant endostatin as the immunogen.

products categories :

Cytokines & Growth Factors

products description :

Mouse monoclonal Endostatin antibody

ncbi gi num :

13957730

ncbi acc num :

AAK50626.1

uniprot acc num :

P39060

ncbi mol weight :

135,761 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Direct P53 Effectors Pathway (137939); Extracellular Matrix Organization Pathway (576262); FOXA1 Transcription Factor Network Pathway (137979); Integrin Cell Surface Interactions Pathway (106110)

ncbi summary :

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: extracellular matrix; extracellular space; collagen; endoplasmic reticulum lumen; extracellular region; basement membrane. Molecular Function: identical protein binding; protein binding; metal ion binding; structural molecule activity. Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; negative regulation of cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; visual perception; positive regulation of cell proliferation; endothelial cell morphogenesis; angiogenesis; cell adhesion; response to hydrostatic pressure; positive regulation of cell migration. Disease: Knobloch Syndrome 1

size1 :

0.1 mg

price1 :

395 USD

more info or order :

MyBioSource product webpage