antibody

14.3.3 beta antibody

MBS533204

0.1 ml

360 USD

monoclonal

mouse

nonconjugated

J2E9

western blot, ELISA, enzyme immunoassay

Antibody

14.3.3 beta antibody

14.3.3 beta

Monoclonal 14.3.3 beta; Anti-14-3-3 beta; Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein; KCIP-1; HS 1; beta polypeptide 14 3 3 protein beta/alpha; 14-3-3 beta; Protein kinase C inhibitor protein 1; 14/3/3 beta; 14.3.3 beta; HS1; Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein beta Polypeptide; Protein 1054; beta polypeptide; GW128; KCIP 1; YWHAB; Brain protein 14 3 3 beta isoform; GW 128; KCIP1

14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1

14.3.3 beta

YWHAB; YWHAB; HS1; GW128; YWHAA; KCIP-1; HEL-S-1; KCIP-1

1433B_HUMAN

Monoclonal

IgG2a kappa

J2E9

Mouse

To be determined by end-user.

246

Human

14-3-3 beta antibody was purified by protein-G affinity chromatography

Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.

1 mg/ml

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Western Blot (WB)

WB: 1:1,000-1:2,000

Source Note: Anti-human 14-3-3 beta antibody, clone J2E9, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human YWHAB protein. Biological Significance: The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms,beta, gamma,epsilon, sigma, zeta, tau and theta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery.

Immunogen: 14-3-3 beta antibody was raised in mouse using recombinant human 14-3-3 beta (1-246aa) purified from E Coli as the immunogen.

Signal Transduction

Mouse monoclonal 14-3-3 beta antibody

21328448

NP_647539.1

NM_139323.2

P31946

27,850 Da

ARMS-mediated Activation Pathway 106466!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Axon Guidance Pathway 105688!!Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway 187213!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 530733

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

0.1 ml

360 USD