antibody

p16 antibody

MBS532973

0.1 ml

460 USD

monoclonal

mouse

nonconjugated

1E12E10

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

p16 antibody

p16

Monoclonal p16; Anti-p16; MTS-1; Cyclin-dependent kinase inhibitor 2A isoforms 1/2/3; p 16; Cyclin-dependent kinase 4 inhibitor A; p-16; p16; p16INK4A; p16-INK4; CDK4I; Multiple tumor suppressor 1; p16-INK4a

p16, partial; P16; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A; P16

p16

CDKN2A; CDKN2A; ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

Q208B5_HUMAN

Monoclonal

IgG1

1E12E10

Mouse

Human, Rat, Mouse

67

Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.

1.0 mg/ml

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

ELISA: 1:10,000. IHC: 1:200-1:1000. WB: 1:500-1:2000

Biological Significance: Cyclin-dependent kinase inhibitor 2A is a tumor suppressor protein, which in humans is encoded by the CDKN2A gene. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.

Immunogen: p16 antibody was raised in Mouse using a purified recombinant fragment of P16 expressed in E Coli as the immunogen.

Cancer

Mouse monoclonal p16 antibody

89355819

ABD72255.1

Q208B5

6,862 Da

Apoptosis Pathway 198797!!Apoptosis Modulation And Signaling Pathway 198822!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Cellular Senescence Pathway 905991

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

0.1 ml

460 USD