product summary
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company name :
MyBioSource
product type :
antibody
product name :
BORIS antibody
catalog :
MBS532845
quantity :
0.1 mg
price :
300 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
KT72
application :
western blot, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS532845
products type :
Antibody
products full name :
BORIS antibody
products short name :
BORIS
products name syn :
Monoclonal BORIS; Anti-BORIS; Brother of the Regulator of Imprinted Sites
other names :
BORIS-like protein; Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T
products gene name :
BORIS
other gene names :
CTCFL; BORIS; CT27
uniprot entry name :
CTCFL_HUMAN
clonality :
Monoclonal
isotype :
IgG2a
clone :
KT72
host :
Rat
sequence length :
613
specificity :
Mouse
purity :
BORIS antibody was purified by Protein G chromatography.
form :
Supplied in PBS containing 0.1% sodium azide as a preservative
concentration :
1 mg/ml
storage stability :
Store at 4 degree C for up to 1 month. For long term storage, aliquot and store at -20 to -80 degree C. Avoid repeated freeze/thaw cycles.
tested application :
Immunofluorescence (IF), Western Blot (WB)
app notes :
IF: 1-10 ug/ml. WB: 0.1-1 ug/ml
other info1 :
Biological Significance: BORIS is a novel male germ-line-specific protein associated with epigenetic reprogramming events.
other info2 :
Biohazard Information: This product contains sodium azide which is hazardous. Immunogen: BORIS antibody was raised in Rat using Mouse BORIS as the immunogen.
products categories :
DNA & RNA
products description :
Rat monoclonal BORIS antibody
ncbi gi num :
82882230
ncbi acc num :
ABB92839.1
ncbi mol weight :
35,417 Da
uniprot summary :
BORIS: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 Arg-3 to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family. Protein type: C2H2-type zinc finger protein; DNA-binding; Cancer Testis Antigen (CTA). Chromosomal Location of Human Ortholog: 20q13.31. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; histone binding; sequence-specific DNA binding; metal ion binding. Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; DNA methylation during gametogenesis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of histone H3-K4 methylation; cell cycle
size1 :
0.1 mg
price1 :
300 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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