catalog number :
MBS532515
products full name :
Hemoglobin epsilon antibody (FITC)
products short name :
Hemoglobin epsilon
products name syn :
Monoclonal Hemoglobin epsilon; Anti-Hemoglobin epsilon; Hemoglobin
other names :
hemoglobin subunit epsilon; Hemoglobin subunit epsilon; hemoglobin subunit epsilon; hemoglobin, epsilon 1; Epsilon-globin; Hemoglobin epsilon chain
other gene names :
HBE1; HBE1; HBE; HBE
uniprot entry name :
HBE_HUMAN
specificity :
Hemoglobin epsilon
form :
PBS, pH 7.4, 10mM NaN3.
concentration :
1.0 mg/ml (by UV absorbance at 280nm)
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA)
app notes :
ELISA: 1:100,000
other info1 :
Biological Significance: Hemoglobin Gower-1 is found as a minor Hb in the early embryo. It disappears by the third month of pregnancy in favour of haemoglobin Gower-2 and haemaglobin Portland and then Hb F. The zeta chain has 141 amino acid residues. Synthesis of the zeta chain is deficient in cases of hydrops foetalis.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Tag/Conjugate: FITC. Immunogen: Hemoglobin epsilon antibody (FITC) was raised in mouse using hemoglobin gower-I (alpha2 epsilon2) isolated from culture fluids of the cell line K562 as the immunogen.
products categories :
Nutrition & Metabolism; Conjugated Monoclonal Antibodies
products description :
Mouse monoclonal Hemoglobin epsilon antibody (FITC)
ncbi acc num :
NP_005321.1
ncbi gb acc num :
NM_005330.3
ncbi mol weight :
16,203 Da
ncbi pathways :
Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196); Hemostasis Pathway (106028)
ncbi summary :
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
uniprot summary :
HBE1: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. Belongs to the globin family. Protein type: Carrier. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: hemoglobin complex; cytosol. Molecular Function: iron ion binding; heme binding; hemoglobin alpha binding; oxygen binding; oxygen transporter activity. Biological Process: protein heterooligomerization; oxygen transport; negative regulation of transcription from RNA polymerase II promoter; blood coagulation