antibody

CXCR1 antibody (FITC)

MBS532470

100 Tests

515 USD

monoclonal

mouse

FITC

M12638

Antibody

CXCR1 antibody (FITC)

CXCR1

Monoclonal CXCR1; Anti-CXCR1; CXCR 1; interleukin 8 receptor alpha; il8r1; il-8ra; CXCR1; CXCR-1; interleukin-8 receptor a; cxcr1; interleukin-8 receptor type a; il-8 receptor a

CXCR1; C-X-C chemokine receptor type 1; C-X-C chemokine receptor type 1; chemokine (C-X-C motif) receptor 1; CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181

CXCR1

CXCR1; CXCR1; C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1; CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A

CXCR1_HUMAN

Monoclonal

IgG2a

M12638

Mouse

Human IL-8

350

Liquid in saline with 0.5% BSA and 0.1% NaN3.

100 tests (0.05mg/ml)

Store at 4 degree C. Store in the dark.

User optimized

Biological Significance: CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (otherwise known as interleukin-8) and CXCL6 can both bind CXCR1 in humans, while all other ELR-positive chemokines, such as CXCL1 to CXCL7 bind only CXCR2. They are both expressed on the surface of neutrophils in mammals.

Tag/Conjugate: FITC

Cytokines & Growth Factors; Conjugated Monoclonal Antibodies

Mouse monoclonal CXCR1 antibody

62911779

AAY21515.1

P25024

39,791 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (515)

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, cytokine; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: membrane; plasma membrane; integral to membrane. Molecular Function: G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding. Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response. Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

100 Tests

515 USD