catalog number :
MBS532362
products full name :
IFNGR2 antibody
products short name :
IFNGR2
products name syn :
Monoclonal IFNGR2; Anti-IFNGR2; IFN gamma Receptor beta chain; IFNGR-2; IFNGR2; IFNGR 2; Interferon gamma Receptor 2; CD118
other names :
interferon gamma receptor 2; Interferon gamma receptor 2; interferon gamma receptor 2; interferon gamma receptor 2 (interferon gamma transducer 1); Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma transducer 1
products gene name :
IFNGR2
other gene names :
IFNGR2; IFNGR2; AF-1; IFGR2; IMD28; IFNGT1; IFNGT1; IFN-gamma receptor 2; IFN-gamma-R2; AF-1
uniprot entry name :
INGR2_HUMAN
reactivity :
To be determined by end-user
form :
Supplied as a liquid in PBS with 0.1% BSA.
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
other info1 :
Biological Significance: Interferons (IFNs) are proteins made and released by lymphocytes in response to the presence of pathogens-such as viruses, bacteria, or parasites-or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Bioactivity: Binds to but does not neutralize human interferon gamma receptor
other info2 :
Immunogen: IFNGR2 antibody was raised in mouse using human interferon gamma receptor chain 2 as the immunogen.
products categories :
Immunology
products description :
Mouse monoclonal IFNGR2 antibody
products references :
Cultured adult porcine astrocytes and microglia express functional interferon-gamma receptors and exhibit toxicity towards SH-SY5Y cells; Vlad A. Ionescua, Erika B. Villanuevaa, Sadayuki Hashiokab, Manpreet Bahniwala, Andis Klegeris (Brain Research Bulletin: Volume: 84 Issue: 3 Page: 244-251 DOI: 10.1016/j.brainresbull.2010.12.011). Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro; Sadayuki Hashiokaa, Andis Klegerisb, Claudia Schwaba, Sheng Yua, Patrick L. McGeer (Journal of Neuroimmunology: Volume: 225 Issue: 1-2 Page: 91-99 DOI: 10.1016/j.jneuroim.2010.04.023)
ncbi acc num :
NP_005525.2
ncbi gb acc num :
NM_005534.3
ncbi mol weight :
37,806 Da
ncbi pathways :
Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!HIF-1 Signaling Pathway 695200!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!Immune System Pathway 106386!!Inflammatory Bowel Disease (IBD) Pathway 842771
ncbi summary :
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]